Tag: atherosclerosis

Free Download The Mechanobiology in Atherosclerosis: Basic, Frontier and Advance
English | 2024 | ISBN: 9819765110 | 245 Pages | PDF (True) | 27 MB
This book is based on prior research conducted by the author’s team, integrating the latest advancements in biomechanics and mechanobiology related to atherosclerosis from both domestic and international peers. It explores the mechanobiological mechanisms and prevention strategies for atherosclerosis and intravascular stent restenosis. The topics covered include: lipoprotein concentration polarization, stress response of vascular endothelial cells, biomechanical mechanisms in cardiovascular and cerebrovascular development, atherosclerotic plaque formation, in-stent restenosis, and post-stent implantation atherosclerosis. Additionally, the book presents the mechanobiological mechanisms of drug regulation for cell viability and inhibition of vascular restenosis, as well as the latest frontiers and advancements in these areas. It carries significant reference value for postgraduates and young researchers in cardiovascular physiology and pathology, particularly those involved in biomedical engineering, basic medicine, and clinical medicine focused on atherosclerotic disease research.

Free Download Cholesterol Crystals in Atherosclerosis and Other Related Diseases
English | 2023 | ISBN: 3031411919 | 499 Pages | PDF (True) | 31 MB
This book is the first authoritative and comprehensive text dedicated to the understanding of how cholesterol triggers vascular inflammation and mechanical injury that leads to heart attacks, strokes as well as other organ and tissue pathology. It includes chapters on the background of cholesterol crystal formation and methods for their detection as well as a description of the physiochemical transformation of metastable ‘liquid’ cholesterol to a solid flat plate crystalloid within the cellular and extracellular environment resulting in volume expansion. Chapters also discusses cholesterol crystals and other crystalloid molecules found in atherosclerotic plaque. In addition, the book examines how cholesterol crystals can induce similar injurious processes in other organs including the retina of the eye to cause blindness, in solid cancers causing further tumor growth and in the brain of patients with Alzheimer’s. And lastly, the book addresses various potential therapeutics that disrupt the physiochemical transformation of cholesterol from a liquid to a solid, inhibit its role in triggering inflammation and tissue injury while ushering a path towards targeted therapies.

Free Download Metallocorroles for Attenuation of Atherosclerosis by Adi Haber
English | PDF | 2012 | 101 Pages | ISBN : 3642303277 | 4.5 MB
Adi Haber’s thesis summarises the use of a new entity, the corrole, to combat one of the major cardiovascular diseases, atherosclerosis. She examines the effects of three rationally designed corrole-metal complexes on some of the many variables which contribute to the development of atherosclerosis. There is a focus on both the "bad" and "good" cholesterol carriers, LDL and HDL. Adi Haber proceeds from basic findings in pure chemistry through biochemical and cell culture tests to in vivo examinations. The work in this thesis shows that corroles are highly efficient both for early and late treatment of atherosclerosis in animals. These results will pave the way for ongoing regulated preclinical studies focussed on the development of metallocorroles as potential drugs for treating cardiovascular diseases.