Tag: CNS

Critical Pathways to Success in CNS Drug Development


Free Download Critical Pathways to Success in CNS Drug Development By Neal R. Cutler, John J. Sramek, Michael F. Murphy, Henry Riordan, Peter Biek, Angelico Carta
2010 | 272 Pages | ISBN: 1444330640 | PDF | 2 MB
Covering the latest advances in CNS drug development, this book will guide all those involved in pre-clinical to early clinical trials. The authors describe how recent innovations can accelerate the development of novel CNS compounds, improve early detection of efficacy and toxicity signals, and increase the safety of later-stage clinical trials.The current crisis in the drug development industryis critically reviewed, as well as the steps needed to correct the problems, including new government-backed regulations and industry-based innovations designed to accelerate CNS drug development in the future.Animal-based models of major CNS disordersare described in detail, and the ability of the latest in vitro and computer-based models to simulate CNS disease states and predict drug efficacy and side-effects are examined. Particular attentionis given to the growing use of biomarkers and how they can be used effectively in early human trials as signals of potential drug efficacy, as well as the increasingly important role of imaging studies to guide dose selection. Cognitive assessments that can be useful indicators of effect in patient populations are also discussed.Written by a team of clinical scientists involved in CNS drug trials for over 20 years, and based on a wealth of drug development and clinical trial experience, Critical Pathways to Success in CNS Drug Developmentis full of practical advice for successfully designing and executing CNS drug trials, avoiding potential pitfalls, and complying with government regulations

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Adult CNS Radiation Oncology Principles and Practice (2024)


Free Download Adult CNS Radiation Oncology: Principles and Practice by Eric L. Chang
English | EPUB | 2018 | 746 Pages | ISBN : 3319428772 | 150.2 MB
This book elucidates the radiation therapy protocols and procedures for the management of adult patients presenting with primary benign and malignant central nervous system tumors. With the development of new treatment strategies and rapid advancement of radiation technology, it is crucial for radiation oncologists to maintain and refine their knowledge and skills. Dedicated exclusively to adult CNS radiation oncology, this textbook explores CNS tumors ranging from the common to the esoteric as well as secondary cancers of metastatic origin.

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