Tag: Combination

Cunning Combination Problems & Other Puzzles


Free Download Ivan Moscovich, "Cunning Combination Problems & Other Puzzles "
English | ISBN: 1402723466 | 2005 | 128 pages | PDF | 10 MB
There’s magic in these brainteasers. Most of them play variations on the magic square, among the oldest puzzles that exist. These cubes or other shapes are made up of groups of cells, each cell containing one of a set of numbers. The set generally corresponds with the number of cells, so, for example, a five-by-five magic square would contain numbers from 1 to 25. The trick: the sum of the numbers in any one row or column (and sometimes diagonal) must be the same. It’s pure mathematical beauty. Examine and attempt to figure out the workings of a "diabolic" version created by Dürer, an early variation by Lo-Shu, and variants that use colors, different shapes, and hinged tiles.

(more…)

Combination Cancer Therapy Modulators and Potentiators


Free Download Combination Cancer Therapy: Modulators and Potentiators By Jose Baselga MD (auth.), Gary K. Schwartz MD (eds.)
2005 | 284 Pages | ISBN: 1588292002 | PDF | 2 MB
Early clinical trials of the new molecular-based anticancer agents have shown that many are marginal in controlling cancer, but prove to be potent modulators and potentiators of chemotherapy-induced apoptosis when used in combination with classic cytotoxic drugs or radiation. In Combination Cancer Therapy: Modulators and Potentiators, expert physician-scientists and clinicians with first-hand experience in the clinical development of targeted therapies review those combinations that hold the most promise for the future of medical oncology, detailing their optimal sequence, pharmacokinetic interactions, and interaction with downstream cellular signals. The combinations run the gamut of targeted therapies against cell surface receptors (EGF-R and HER2), the cell cycle (the CDKs), signal transduction events (PKC and NF-kB), apoptosis (bcl-2), as well as focused therapies in ovarian cancer, hematologic diseases, and breast cancer. The authors emphasize novel translational approaches that are rapidly moving from the laboratory benchtop to the patient’s bedside as a new generation of cancer therapeutics. Cutting-edge and forward-looking, Combination Cancer Therapy: Modulators and Potentiators offers everyone in the fields of cancer drug development and therapy a powerful new understanding of the optimal sequencing and scheduling of new combination drug therapies necessary to maximize the effects for cancer patients today.

(more…)

Tillage Machinery-Passive, Active and Combination


Free Download Tillage Machinery-Passive, Active and Combination by Hifjur Raheman , Pranay Sarkar
English | PDF EPUB (True) | 2024 | 194 Pages | ISBN : 9819963303 | 39.2 MB
This textbook comprehensively covers the fundamental concepts of tillage operation, including all the three kinds of tillage implements, viz. passive, active and combination. It discusses functional analysis, principle of operation, and testing of main tillage machinery. This textbook includes the design procedure and numerical examples to reinforce the theoretical concepts. It incorporates a lucid style of writing with easy-to-understand design procedure of different tillage implements. This textbook is highly useful for graduate and postgraduate students studying farm machinery and power engineering, design of agricultural machines, and allied fields.

(more…)