Tag: Drug

Free Download M. Rami Reddy, Mark D. Erion, "Free Energy Calculations in Rational Drug Design"
English | 2001 | ISBN: 1441933727 | PDF | pages: 401 | 18.9 mb
Free energy calculations represent the most accurate computational method available for predicting enzyme inhibitor binding affinities. Advances in computer power in the 1990s enabled the practical application of these calculations in rationale drug design. This book represents the first comprehensive review of this growing area of research and covers the basic theory underlying the method, numerous state of the art strategies designed to improve throughput and dozen examples wherein free energy calculations were used to design and evaluate potential drug candidates.

Free Download Advanced Computer-Assisted Techniques in Drug Discovery, Second Edition By
1995 | 361 Pages | ISBN: 3527292489 | PDF | 7 MB
The use of powerful computers has revolutionized molecular design and drug discovery. Thoroughly researched and well-structured, this comprehensive handbook covers highly effective and efficient techniques in 3D-QSAR and advanced statistical analysis. The emphasis is on showing users how to apply these methods and avoid costly and time-consuming methodical errors. Topics covered include * combination of statistical methods and molecular modeling tools * rational use of databases * advanced statistical techniques * neural networks and expert systems in molecular design This book addresses the practitioner in industry and research, as well as the novice wishing to become acquainted with modern tools in medicinal chemistry. Content: Chapter 1 Introduction (pages 1-7): Han van de WaterbeemdChapter 2 3D QSAR The Integration of QSAR with Molecular Modeling (pages 9-88): Demetrio Pitea, Ugo Cosentino, Giorgio Moro, Laura Bonati, Elena Fraschini, Murina Lasagni, Roberto Todeschini, Andrew M. Davis, Gabriele Cruciani and Sergio ClementiChapter 3 Rational Use of Chemical and Sequence Databases (pages 89-162): Mark A. Johnson, Gerald M. Maggiora, Michael S. Lajiness, Joseph B. Moon, James D. Petke, Douglas C. Rohrer, Geoffrey M. Downs, Peter Willett, Paul J. Lewi and Henri MoereelsChapter 4 Advanced Statistical Techniques (pages 163-292): Jonathan A. Malpass, David W. Salt, Martyn G. Ford, E. Watcyn Wynn, David J. Livingstone, Jean?Christophe Dore, Tiiu Ojasoo, Valerie S. Rose, John Wood, Halliday J. H. MacFie and Klaus?Jurgen SchaperChapter 5 Neural Networks and Expert Systems in Molecular Design (pages 293-331): David T. Manallack, David J. Livingstone, Mohammed A?Razzak and Robert C. Glen

Free Download Dr. Michael R. Frone PhD, "Alcohol and Illicit Drug Use in the Workforce and Workplace"
English | ISBN: 1433812444 | 2012 | 269 pages | PDF | 3 MB
In this authoritative book, Michael R. Frone takes a close look at what we know and don’t know about workforce and workplace substance involvement. In doing so, he exposes the lack of evidence behind many popular myths regarding employee substance involvement. Frone’s review covers research conducted over the past 30 years, and he analyzes methodological limitations and the tendency to "go beyond the data" when interpreting results. Given the need for evidence-based management and policy, this book will be a comprehensive resource for researchers and practitioners in management, occupational health, and addiction treatment and prevention.

Free Download Dr. Robert Margolis PhD, "Treating Patients With Alcohol and Other Drug Problems: An Integrated Approach "
English | ISBN: 1433809656 | 2011 | 270 pages | PDF | 2 MB
In this new edition of Treating Patients With Alcohol and Other Drug Problems, scholar-practitioners Robert D. Margolis and Joan E. Zweben reprise their treatment-oriented survey of assessing alcohol and other drug (AOD) problems for practitioners to make informed referrals of clients in a variety of intake settings. And although referral is certainly appropriate in many cases, this new edition of the book seeks to enhance the confidence and skill of psychotherapists and other practitioners in addressing alcohol and drug use in the context of their ongoing work.

Free Download President Lawrence M Scheier, "Handbook of Drug Use Etiology: Theory, Methods, and Empirical Findings"
English | ISBN: 1433804468 | 2009 | 784 pages | PDF | 64 MB
This title presents differing theoretical perspectives and a mix of viewpoints on causation, consequences, prevention practices, and policy. It details important emerging areas of study on this topic, such as genetics, race, and age. It links drug use etiology to other areas of behavioral science. It presents implications of the science on policy and practice.

Free Download Bioequivalence Studies in Drug Development: Methods and Applications By Dieter Hauschke, Volker Steinijans, Iris Pigeot(auth.)
2007 | 321 Pages | ISBN: 0470094753 | PDF | 7 MB
Studies in bioequivalence are the commonly accepted method to demonstrate therapeutic equivalence between two medicinal products. Savings in time and cost are substantial when using bioequivalence as an established surrogate marker of therapeutic equivalence. For this reason the design, performance and evaluation of bioequivalence studies have received major attention from academia, the pharmaceutical industry and health authorities. Bioequivalence Studies in Drug Development focuses on the planning, conducting, analysing and reporting of bioequivalence studies, covering all aspects required by regulatory authorities. This text presents the required statistical methods, and with an outstanding practical emphasis, demonstrates their applications through numerous examples using real data from drug development. Includes all the necessary pharmacokinetic background information. Presents parametric and nonparametric statistical techniques. Describes adequate methods for power and sample size determination. Includes appropriate presentation of results from bioequivalence studies. Provides a practical overview of the design and analysis of bioequivalence studies. Presents the recent developments in methodology, including population and individual bioequivalence. Reviews the regulatory guidelines for such studies, and the existing global discrepancies. Discusses the designs and analyses of drug-drug and food-drug interaction studies. Bioequivalence Studies in Drug Development is written in an accessible style that makes it ideal for pharmaceutical scientists, clinical pharmacologists, and medical practitioners, as well as biometricians working in the pharmaceutical industry. It will also be of great value for professionals from regulatory bodies assessing bioequivalence studies.Content: Chapter 1 Introduction (pages 1-16): Chapter 2 Metrics to Characterize Concentration?Time Profiles in Single? and Multiple?Dose Bioequivalence Studies (pages 17-36): Chapter 3 Basic Statistical Considerations (pages 37-68): Chapter 4 Assessment of Average Bioequivalence in the RT/TR design (pages 69-104): Chapter 5 Power and Sample Size Determination for Testing Average Bioequivalence in the RT/TR Design (pages 105-122): Chapter 6 Presentation of Bioequivalence Studies (pages 123-155): Chapter 7 Designs with more than Two Formulations (pages 157-173): Chapter 8 Analysis of Pharmacokinetic Interactions (pages 175-203): Chapter 9 Population and Individual Bioequivalence (pages 205-282): Chapter 10 Equivalence Assessment for Clinical Endpoints (pages 283-306):

Free Download Nano Drug Delivery for Cancer Therapy: Principles and Practices by Firdos Alam Khan
English | January 9, 2024 | ISBN: 9819969395 | 264 pages | MOBI | 7.14 Mb
This book discusses the various modes and methods of nano-based drug delivery in different types of cancers such as colon, breast, cervical, ovarian, and lung cancer. It reviews the significance of nano drug delivery in cancer therapy, the application of nanoparticles in overcoming drug resistance, targeted therapy, and immunotherapy. The book also covers topics related to the synthesis of different types, shapes, and sizes of nanocarriers using synthetic and biological approaches. Further, a chapter explores the synthesis of nanocarriers loaded with anti-cancer drugs by using functionalization or conjugations and encapsulation methods. The book also examines the nanocarriers as delivery vehicles for chemotherapeutic agents against cancers using in vitro and animal models of cancers, preclinical trials for efficacy, and safety profiling of nanocarriers. Finally, future trends and innovation in nano drug delivery for cancer therapy, application of siRNA (nanoparticle-based RNA)therapy, ultrasound-linked nano-cancer therapeutics, and application of exosome-based cancer therapy topics are discussed. Towards the end, the book examines the limitations of nanocarriers, including the cell and tissue toxicity, genotoxicity, and scale-up of nanomaterials, health and environmental hazards associated with nanoformulation synthesis, respiratory diseases, government regulations, and ethical issues.

Free Download Oral Bioavailability and Drug Delivery: From Basics to Advanced Concepts and Applications (Wiley Series in Drug Discovery and Development) by Ming Hu, Xiaoling Li
English | February 13, 2024 | ISBN: 1119660653 | 928 pages | EPUB | 53 Mb
ORAL BIOAVAILABILITY AND DRUG DELIVERY

Free Download Baudelaire in Chains: A Portrait of the Artist as a Drug Addict by Frank Hilton
English | November 1, 2003 | ISBN: 0720611806 | True EPUB | 256 pages | 1.98 MB
An acclaimed and most unusual biography of Baudelaire, showing him ensnared by his passions for poetry, prostitutes, and drugs.

Free Download Baudelaire in Chains: A Portrait of the Artist as a Drug Addict by Frank Hilton
English | November 1, 2003 | ISBN: 0720611806 | True EPUB | 256 pages | 1.98 MB
An acclaimed and most unusual biography of Baudelaire, showing him ensnared by his passions for poetry, prostitutes, and drugs.