Tag: Drug

Free Download WHO Regional Office for South-East Asia, "Management of Common Health Problems of Drug Users"
English | 2009 | pages: 139 | ISBN: 9290222921 | PDF | 0,8 mb
Primary health care for drug users aims to promote health by providing a comprehensive harm-reduction package including outreach; peer-led interventions; information, education and communication; condoms; sterile injection equipment; and effective drug treatment including opioid substitution therapy. It also aims to reduce morbidity and mortality among all drug users by early identification and treatment of infections and other drug use-related illnesses; and provide care, treatment and support for HIV-infected drug users.

Free Download Computational Drug Discovery
by Pooja A. Chawla, Dilpreet Singh, Kamal Dua, Muralikrishnan Dhanasekaran, Viney Chawla
English | 2024 | ISBN: 3111206696 | 440 pages | True PDF EPUB | 107.41 MB

Free Download Computational Drug Delivery
by Pooja A. Chawla, Dilpreet Singh, Kamal Dua, Muralikrishnan Dhanasekaran, Viney Chawla
English | 2024 | ISBN: 3111208648 | 448 pages | True PDF EPUB | 103.34 MB

Free Download Traditional Resources and Tools for Modern Drug Discovery: Ethnomedicine and Pharmacology
English | 2024 | ISBN: 9819745993 | 1123 Pages | PDF EPUB (True) | 48 MB
This book provides perspectives on the combinatorial approach of plant-based compounds for drug discovery to achieve better disease-curing outcomes introducing the evolution of ethnobotany and traditional medicine in modern drug development. It covers the biotechnological interventions for the identification and screening of compounds and their optimization to enhance affinity, selectivity, bioavailability, and metabolic stability. While overviewing how essential compounds are successfully identified from herbal/ medicinal plants and utilized in the form of effective drugs which eventually have helped in combating long-term diseases in humans, the book also provides a better understanding of how infection and the diseases caused are regulated at the molecular and physiological stages. The book also highlights the importance of bioactive compounds in modern drug discovery and the perspectives for a potential industrial application. The chapters are developed by eminent subject experts with due care and clarity and cover an up-to-date literature review with relevant illustrations. The book would cater to the needs of undergraduate and graduate students, researchers, and scientists, and may attract the attention of pharmaceutical companies/industrialists and health policymakers.

Free Download Ben Dunn, "Proteinases as Drug Targets"
English | 2011 | ISBN: 1849730490 | PDF | pages: 293 | 163.7 mb
This unique book describes newly discovered proteolytic enzymes and their biological function. In many cases, these enzymes are targets for new drug discovery in order to provide new therapeutic approaches to control human diseases and/or metabolic conditions. The chapters in this book will help other investigators to pursue drug discovery by detailing methods of production and assay of the enzymes. In addition, the latest structural studies that are described in the book will permit rapid advances in drug design. The most important elements of this book are the state-of-the-art, detailed descriptions of the properties of the proteolytic enzymes. The chapters in the book, written by leading experts in the field, collect the best work on the topics with complete bibliographies for each target enzyme. The illustrations are highly informative to aid and facilitate a new design of inhibitors that can be developed as drug candidates. Key chapters include those by Mark Gorrell and Catherine Abbott, both describing dipeptidyl peptidases, which have been implicated in a number of metabolic conditions including diabetes. The chapters are written from two very different perspectives, thus enriching the literature in this area. In addition, the chapter by Sheena McGowan focuses on aminopeptidases from the malaria parasite, Plasmodium falciparum, and the chapter by Ben Dunn deals with the aspartic peptidases from the same organism.

Free Download M. Rami Reddy, Mark D. Erion, "Free Energy Calculations in Rational Drug Design"
English | 2001 | ISBN: 1441933727 | PDF | pages: 401 | 18.9 mb
Free energy calculations represent the most accurate computational method available for predicting enzyme inhibitor binding affinities. Advances in computer power in the 1990s enabled the practical application of these calculations in rationale drug design. This book represents the first comprehensive review of this growing area of research and covers the basic theory underlying the method, numerous state of the art strategies designed to improve throughput and dozen examples wherein free energy calculations were used to design and evaluate potential drug candidates.

Free Download Advanced Computer-Assisted Techniques in Drug Discovery, Second Edition By
1995 | 361 Pages | ISBN: 3527292489 | PDF | 7 MB
The use of powerful computers has revolutionized molecular design and drug discovery. Thoroughly researched and well-structured, this comprehensive handbook covers highly effective and efficient techniques in 3D-QSAR and advanced statistical analysis. The emphasis is on showing users how to apply these methods and avoid costly and time-consuming methodical errors. Topics covered include * combination of statistical methods and molecular modeling tools * rational use of databases * advanced statistical techniques * neural networks and expert systems in molecular design This book addresses the practitioner in industry and research, as well as the novice wishing to become acquainted with modern tools in medicinal chemistry. Content: Chapter 1 Introduction (pages 1-7): Han van de WaterbeemdChapter 2 3D QSAR The Integration of QSAR with Molecular Modeling (pages 9-88): Demetrio Pitea, Ugo Cosentino, Giorgio Moro, Laura Bonati, Elena Fraschini, Murina Lasagni, Roberto Todeschini, Andrew M. Davis, Gabriele Cruciani and Sergio ClementiChapter 3 Rational Use of Chemical and Sequence Databases (pages 89-162): Mark A. Johnson, Gerald M. Maggiora, Michael S. Lajiness, Joseph B. Moon, James D. Petke, Douglas C. Rohrer, Geoffrey M. Downs, Peter Willett, Paul J. Lewi and Henri MoereelsChapter 4 Advanced Statistical Techniques (pages 163-292): Jonathan A. Malpass, David W. Salt, Martyn G. Ford, E. Watcyn Wynn, David J. Livingstone, Jean?Christophe Dore, Tiiu Ojasoo, Valerie S. Rose, John Wood, Halliday J. H. MacFie and Klaus?Jurgen SchaperChapter 5 Neural Networks and Expert Systems in Molecular Design (pages 293-331): David T. Manallack, David J. Livingstone, Mohammed A?Razzak and Robert C. Glen

Free Download Dr. Michael R. Frone PhD, "Alcohol and Illicit Drug Use in the Workforce and Workplace"
English | ISBN: 1433812444 | 2012 | 269 pages | PDF | 3 MB
In this authoritative book, Michael R. Frone takes a close look at what we know and don’t know about workforce and workplace substance involvement. In doing so, he exposes the lack of evidence behind many popular myths regarding employee substance involvement. Frone’s review covers research conducted over the past 30 years, and he analyzes methodological limitations and the tendency to "go beyond the data" when interpreting results. Given the need for evidence-based management and policy, this book will be a comprehensive resource for researchers and practitioners in management, occupational health, and addiction treatment and prevention.

Free Download Dr. Robert Margolis PhD, "Treating Patients With Alcohol and Other Drug Problems: An Integrated Approach "
English | ISBN: 1433809656 | 2011 | 270 pages | PDF | 2 MB
In this new edition of Treating Patients With Alcohol and Other Drug Problems, scholar-practitioners Robert D. Margolis and Joan E. Zweben reprise their treatment-oriented survey of assessing alcohol and other drug (AOD) problems for practitioners to make informed referrals of clients in a variety of intake settings. And although referral is certainly appropriate in many cases, this new edition of the book seeks to enhance the confidence and skill of psychotherapists and other practitioners in addressing alcohol and drug use in the context of their ongoing work.

Free Download President Lawrence M Scheier, "Handbook of Drug Use Etiology: Theory, Methods, and Empirical Findings"
English | ISBN: 1433804468 | 2009 | 784 pages | PDF | 64 MB
This title presents differing theoretical perspectives and a mix of viewpoints on causation, consequences, prevention practices, and policy. It details important emerging areas of study on this topic, such as genetics, race, and age. It links drug use etiology to other areas of behavioral science. It presents implications of the science on policy and practice.