Tag: Epidemiological

Free Download Investigative Electrocardiography in Epidemiological Studies and Clinical Trials By Pentti Rautaharju MD, PhD, Farida Rautaharju PhD (auth.)
2007 | 289 Pages | ISBN: 1846284651 | PDF | 2 MB
Electrocardiology is a relatively new modality in clinical trials, but electrocardiograms (ECGs) have already become established as a valuable research tool for investigation of morbidity and mortality risk associated with various clinical and subclinical conditions. ECGs have also become a crucial tool when investigating adverse cardiac events associated with administration of new drugs.Investigative Electrocardiography in Epidemiological Studies and Clinical Trials reviews the prevalence and incidence and emphasizes the prognostic implications of common ECG abnormalities in contrasting populations. It provides a comprehensive, penetrating and critical analysis of topics such as QT prolongation in clinical drug trials, left ventricular hypertrophy, myocardial ischemia/infarction and epidemiological consideration of relative risks associated with ECG abnormalities. As such it is an essential tool in epidemiological or clinical research using ECGs and in investigations of possible adverse responses of new pharmacological agents.With emphasis on providing international coverage of the topic, the well-respected authors present key information on ECG procedures, epidemiology, problem areas, mortality and morbidity risk. These topics are of particular interest to electrocardiologists, investigators in active ECG research in medical clinics participating in clinical trials, epidemiologists, cardiologists, pharmaceutical companies and regulatory bodies.

Free Download Filoviruses: A Compendium of 40 Years of Epidemiological, Clinical, and Laboratory Studies By Jens H. Kuhn MD, ScD, MS (auth.)
2008 | 413 Pages | ISBN: 3211206701 | PDF | 8 MB
The filoviruses (Lake Victoria marburgvirus and ebolaviruses) are etiological agents of severe hemorrhagic fevers with extraordinary high case-fatality rates for humans, chimpanzees, gorillas, and probably other animals. Many institutions and experts consider them as potential threats to humanity because they could be used as biological weapons. This book summarizes in detail the contemporary knowledge of filoviruses and diseases they cause. Almost the entirety of the open literature on filoviruses, covering all major scientific and clinical fields, is referenced and summarized in this text, including most of the conference abstracts, book chapters, dissertations, government reports, patents, theses, and journal publications in many languages.The book will provide a robust source of knowledge for filovirologists, virologists and scientists in general, clinicians, students, journalists, and biodefense professionals.

Free Download Epidemiological Research: An Introduction: An Introduction By O. S. Miettinen, I. Karp (auth.)
2012 | 186 Pages | ISBN: 9400745362 | PDF | 2 MB
Having last year published "Up from Clinical Epidemiology & EBM" and also "Epidemiological Research: Terms and Concepts," Miettinen now – this time with collaboration from his junior colleague I. Karp – brings out this further introduction into epidemiological research; and he is now working on an introduction into clinical research, for publication next year. It evidently is Miettinen’s felt time to crystallize the basic understandings he has come to as the culmination of a half-century of concentrated effort to advance the theory of epidemiological and ‘meta-epidemiological clinical’ research.In accord with its title, this book focuses on research to develop the knowledge-base for preventive medicine, which mainly is knowledge about the causal origin -etilogy, etiogenesis – of illness. It first illustrates how wanting this knowledge still is, despite much research; and it then aims to guide the reader to more productive etiogenetic research.This book places much emphasis on the need to assure relevance by principles-guided objects design for the studies, which now remains conspicuously absent from epidemiologists’ concerns. And as for methods design, this book exposes the fallacies in the still-common ‘cohort’ and ‘case-control’ studies, defines the essentials of all etiogenetic studies, and then addresses the true options for design in this framework of shared essentials.A good deal of attention is also given to the still commonly-held, very major, twin fallacies that screening for an illness is a preventive intervention, to be studied by randomized trials, and that research on it can imply rational guidelines or recommendations regarding decisions about the screening.While Miettinen already is regarded as ‘the father of modern epidemiology,’ he now appears to have become the father also of post-modern epidemiology, where ‘epidemiology’ still means epidemiological research.