Tag: Epigenetic

Free Download Epigenetic Mechanisms in Breast Cancer Therapy and Resistance
English | 2024 | ISBN: 3031666852 | 111 Pages | PDF EPUB (True) | 21 MB
Epigenetic mechanisms are essential for normal mammalian development and maintenance of gene expression patterns. Disruption of epigenetic processes can lead to altered transcriptional regulation, gene levels, and malignant cellular transformation. Global alterations of the epigenetic landscape are a hallmark of tumorigenesis and metastasis. Conventionally, cancer was thought to be a genetic disease, but recent advancement in the field identified an abundance of epigenetic abnormalities along with genetic alterations. The extensive reprogramming of epigenetic machinery in cancer includes DNA methylation, histone modifications, nucleosome positioning and non-coding RNAs, specifically microRNA expression. Additionally, the reversible nature of epigenetic aberrations has led to the emergence of the promising field of epigenetic therapy, and recent FDA approval of epigenetic drugs for cancer treatment.

Free Download Metabolism and Epigenetic Regulation: Implications in Cancer by Tapas Kumar Kundu, Chandrima Das
English | October 28, 2022 | ISBN: 3031076338 | 635 pages | MOBI | 16 Mb
Metabolic programs of individuals are key determinants for disease susceptibility and immune response. This book, edited by experts in the field, summarizes epigenetic signaling pathways that regulate metabolic programs associated with cancer and cancer-related secondary diseases.

Free Download Chromatin and Epigenetics : An Introduction to Epigenetic Mechanisms (524 Pages)
by Vincenzo Pirrotta
English | 2023 | ISBN: 9811257620 | 525 pages | True PDF | 177.09 MB
This book is an introduction to epigenetics, a controversial term that denotes the mechanisms that instruct the genome on how to express the purely genetic information that encodes proteins. Starting with the discovery of repressor proteins in the 1960s, epigenetics evolved into a kind of user manual for the genetic information, telling the genome if, when, how much and in what cells to read genes. Advances in epigenetics in the past 15 years have revealed how it lies at the heart of virtually every branch of biological and medical sciences and an understanding of its basic principles is therefore essential for every student in this field.