Tag: Epigenetics

Free Download Toxicology and Epigenetics By
2012 | 668 Pages | ISBN: 111997609X | PDF | 8 MB
Epigenetics is the study of both heritable and non-heritable changes in the regulation of gene activity and expression that occur without an alteration in the DNA sequence. This dynamic and rapidly developing discipline is making its impact across the biomedical sciences, in particular in toxicology where epigenetic differences can mean that different individuals respond differently to the same drug or chemical.Toxicology and Epigenetics reflects the multidimensional character of this emerging area of toxicology, describing cutting-edge molecular technologies to unravel epigenetic changes, the use of in vivo and in vitro models, as well as the potential use of toxicological epigenetics in regulatory environments. An international team of experts consider the interplay between epigenetics and toxicology in a number of areas, including environmental, nutritional, pharmacological, and computational toxicology, nanomaterials, proteomics and metabolomics, and cancer research.Topics covered include:environment, epigenetics and diseasesDNA methylation and toxicogenomics chromatin at the intersection of disease and therapyepigenomic actions of environmental arsenicalsenvironment, epigenetics and cardiovascular healthtoxicology, epigenetics and autoimmunityocular epigenomics: potential sites of environmental impact in development and diseasenuclear RNA silencing and related phenomena in animalsepigenomics – impact for drug safety sciencesmethods of global epigenomic profilingtranscriptomics: applications in epigenetic toxicologyToxicology and Epigenetics is an essential insight into the current trends and future directions of research in this rapidly expanding field for investigators, toxicologists, risk assessors and regulators in academia, industry and government.Content: Chapter 1 Introduction (pages 1-3): Saura C. SahuChapter 2 Environment, Epigenetics, and Diseases (pages 5-24): Robert Y. S. Cheng and Wan?yee TangChapter 3 DNA Methylation and Toxicogenomics (pages 25-50): Deepti DeobagkarChapter 4 Chromatin at the Intersection of Disease and Therapy (pages 51-71): Delphine Quenet, Marcin Walkiewicz and Yamini DalalChapter 5 Molecular Epigenetic Changes Caused by Environmental Pollutants (pages 73-109): Solange S. Lewis, Gregory J. Weber, Jennifer L. Freeman and Maria S. SepulvedaChapter 6 Epigenetic Mediation of Environmental Exposures to Polycyclic Aromatic Hydrocarbons (pages 111-127): Bekim Sadikovic and David I. RodenhiserChapter 7 Epigenomic Actions of Environmental Arsenicals (pages 129-148): Paul L. Severson and Bernard W. FutscherChapter 8 Arsenic?Induced Changes to the Epigenome (pages 149-190): Kathryn A. Bailey and Rebecca C. FryChapter 9 Environmental Epigenetics, Asthma, and Allergy: Our Environment’s Molecular Footprints (pages 191-203): Stephanie Lovinsky?Desir and Rachel L. MillerChapter 10 miRNAs in Human Prostate Cancer (pages 205-217): Ernest K. Amankwah and Jong Y. ParkChapter 11 Environment, Epigenetics, and Cardiovascular Health (pages 219-239): Sanjukta Ghosh and Andrea BaccarelliChapter 12 Toxicology, Epigenetics, and Autoimmunity (pages 241-260): Craig A. Cooney and Kathleen M. GilbertChapter 13 Toxicoepigenomics in Lupus (pages 261-274): Donna Ray and Bruce C. RichardsonChapter 14 Ocular Epigenomics: Potential Sites of Environmental Impact in Development and Disease (pages 275-295): Kenneth P. MittonChapter 15 Nuclear RNA Silencing and Related Phenomena in Animals (pages 297-315): Radek Malik and Petr SvobodaChapter 16 Epigenetic Biomarkers in Cancer Detection and Diagnosis (pages 317-338): Ashley G. Rivenbark and William B. ColemanChapter 17 Epigenetic Histone Changes in the Toxicologic Mode of Action of Arsenic (pages 339-356): John F. Reichard and Alvaro PugaChapter 18 Irreversible Effects of Diethylstilbestrol on Reproductive Organs and a Current Approach for Epigenetic Effects of Endocrine Disrupting Chemicals (pages 357-364): Shinichi Miyagawa, Ryohei Yatsu, Tamotsu Sudo, Katsuhide Igarashi, Jun Kanno and Taisen IguchiChapter 19 Epigenomics – Impact for Drug Safety Sciences (pages 365-385): Harri Lempiainen, Raphaelle Luisier, Arne Muller, Philippe Marc, David Heard, Federico Bolognani, Pierre Moulin, Philippe Couttet, Olivier Grenet, Jennifer Marlowe, Jonathan Moggs and Remi TerranovaChapter 20 Archival Toxicoepigenetics: Molecular Analysis of Modified DNA from Preserved Tissues in Toxicology Studies (pages 387-407): B. Alex MerrickChapter 21 Nanoparticles and Toxicoepigenomics (pages 409-426): Manasi P. Jain, Angela O. Choi and Dusica MaysingerChapter 22 Methods of Global Epigenomic Profiling (pages 427-443): Michael W. Y. Chan, Zhengang Peng, Jennifer Chao Weber, Ying?Wei Li, Matthew T. Zuzolo and Huey?Jen L. LinChapter 23 Transcriptomics: Applications in Epigenetic Toxicology (pages 445-458): Pius JosephChapter 24 Carcinogenic Metals Alter Histone Tail Modifications (pages 459-474): Yana Chervona and Max CostaChapter 25 Prediction of Epigenetic and Stochastic Gene Expression Profiles of Late Effects after Radiation Exposure (pages 475-510): Yoko Hirabayashi and Tohru InoueChapter 26 Modulation of Developmentally Regulated Gene Expression Programs through Targeting of Polycomb and Trithorax Group Proteins (pages 511-538): Marjorie Brand and F. J. DilworthChapter 27 Chromatin Insulators and Epigenetic Inheritance in Health and Disease (pages 539-567): Jingping Yang and Victor G. CorcesChapter 28 Bioinformatics for High?Throughput Toxico?Epigenomics Studies (pages 569-588): Maureen A. Sartor, Dana C. Dolinoy, Laura S. Rozek and Gilbert S. OmennChapter 29 Computational Methods in Toxicoepigenomics (pages 589-593): Joo Chuan TongChapter 30 Databases and Tools for Computational Epigenomics (pages 595-614): V. Umashankar and S. GurunathanChapter 31 Interface of Epigenetics and Carcinogenic Risk Assessment (pages 615-630): Paul NioiChapter 32 Epigenetic Modifications in Chemical Carcinogenesis (pages 631-643): Igor P. Pogribny, Igor Koturbash and Frederick A. BelandChapter 33 Application of Cancer Toxicoepigenomics in Identifying High?Risk Populations (pages 645-652): Mukesh Verma and Krishna K. Banaudha

Free Download Epigenetics in Oncology (Cancer Treatment and Research, 190) by Jianjun Chen, G. Greg Wang, Jun Lu
English | December 20, 2023 | ISBN: 303145653X | 399 pages | MOBI | 10 Mb
This book addresses Epigenetics in Cancer and covers the most recent advances in RNA/histone/DNA epigenetics in Oncology. RNA/histone/DNA epigenetics have been shown to play pivotal roles in cancer initiation, progression, maintenance and drug response/resistance, tumor microenvironment, cancer stem cell self-renewal, cancer metabolism, and tumor immune evasion. In particular, research in RNA cancer epigenetics has made impressive progress in the last few years.

Free Download Patho-Epigenetics of Disease By Walter Doerfler MD (auth.), Janos Minarovits, Hans Helmut Niller (eds.)
2012 | 466 Pages | ISBN: 1461433444 | PDF | 5 MB
In multicellular organisms the establishment, maintenance, and programmed alterations of cell-type specific gene expression patterns are regulated by epigenetic mechanisms. Thus, epigenetic alterations (DNA methylation, DNA associated Polycomb-Trithorax protein complexes, histone modifications) ensure the unique transcriptional activity and phenotypic diversity of diploid cells that carry identical or nearly identical DNA sequences.Because DNA methyltransferase I (DNMT1) associates with replication foci during S phase and prefers hemimethylated DNA as a substrate, DNMT1 ensures the clonal propagation of cytosine methylation patterns (maintenance methylation). Thus, DNA methylation may provide a memory function by helping progeny cells to "remember" their proper cellular identity. An alternative system of epigenetic memory, the Polycomb and Trithorax groups of protein complexes, that may operate both independently from and in concert with DNA methylation, ensures the heritable regulation of gene expression via modification of histone tails. The complex interplay of epigenetic regulatory mechanisms permits both the dynamic modulation of gene expression and the faithful transmission of gene expression patterns to each progeny cell upon division. These carefully orchestrated processes can go wrong, however, resulting in epigenetic reprogramming of the cells that may manifest in pathological changes, as it was first realized during the studies of epigenetic alterations in malignant tumors. By now it became a well established fact that not only genetic changes, but also the disruption of epigenetic regulation can result in carcinogenesis and tumor progression. Scientists working in other fields soon followed the pioneering work of cancer researchers, and revealed that epigenetic dysregulation forms the basis of a wide spectrum of human diseases.

Free Download Epigenetics and Health: A Practical Guide by Michelle McCulley
English | February 28, 2024 | ISBN: 1119307988 | 160 pages | MOBI | 0.73 Mb
An incisive and contemporary discussion of epigenetic phenomena applied to human health and disease

Free Download Epigenetics in Biological Communication by Guenther Witzany
English | PDF EPUB (True) | 2024 | 441 Pages | ISBN : 3031592859 | 35.4 MB
Every cell, tissue, organ and organism is competent to use signs to exchange information reaching common coordinations and organisations of both single cell and group behavior. These sign-mediated interactions we term biological communication. The regulatory system that works in development, morphology, cell fate and identity, physiology, genetic instructions, immunity, memory/learning, physical and mental disease depends on epigenetic marks. The communication of cells, persistent viruses and their defectives such as mobile genetic elements and RNA networks ensures both the transport of regulatory instructions and the reprogramming of these instructions. But how are the different states of the epigenome orchestrated? The epigenetic pathways respond to various signaling cues such as DNA methylation, histone variants, histone modifications, chromatin structure, nucleosome remodeling, and epigenetic interactions. Epigenetic signals are responsible for the establishment, maintenance and reversal of transcriptional states that are fundamental for the cell’s ability to memorize past events, such as changes in the external environment, socio-sphere or developmental cues. External signals trigger changes in the epigenome, allowing cells to respond dynamically. Internal signals direct activities that are necessary for body maintenance, and repairing damaged tissues and organs. With the emergence of epigenetic memory, organisms can fix historical and context dependent impressive experiences. Evolution from now on learnt to learn. Learning means organisms can avoid reproduction of always the same. This is key to adaptation. However, inheritance of acquired characteristics is only one of the many examples of the explanatory power of epigenetics. Behavioral epigenetics demonstrates the way in which environmental and social experiences produce individual differences in behaviour, cognition, personality, and mental health. This book assembles experts to outline the various motifs of all kinds of epigenetic regulation of cells throughout their lives.

Free Download Epigenetics in Aquaculture by Francesc Piferrer, Hanping Wang
English | July 3, 2023 | ISBN: 1119821916 | 512 pages | MOBI | 20 Mb
EPIGENETICS IN AQUACULTURE

Free Download Allergy Frontiers: Epigenetics, Allergens and Risk Factors By U. Wahn (auth.), Ruby Pawankar, Stephen T. Holgate, Lanny J. Rosenwasser (eds.)
2009 | 442 Pages | ISBN: 4431728015 | PDF | 9 MB
When I entered the field of allergy in the early 1970s, the standard textbook was a few hundred pages, and the specialty was so compact that texts were often authored entirely by a single individual and were never larger than one volume. Compare this with Allergy Frontiers: Epigenetics, Allergens, and Risk Factors, the present s- volume text with well over 150 contributors from throughout the world. This book captures the explosive growth of our specialty since the single-author textbooks referred to above. The unprecedented format of this work lies in its meticulous attention to detail yet comprehensive scope. For example, great detail is seen in manuscripts dealing with topics such as "Exosomes, naturally occurring minimal antigen presenting units" and "Neuropeptide S receptor 1 (NPSR1), an asthma susceptibility gene." The scope is exemplified by the unique approach to disease entities normally dealt with in a single chapter in most texts. For example, anaphylaxis, a topic usually confined to one chapter in most textbooks, is given five chapters in Allergy Frontiers. This approach allows the text to employ multiple contributors for a single topic, giving the reader the advantage of being introduced to more than one vi- point regarding a single disease.

Free Download Targeting Epigenetics in Inflammatory Lung Diseases by Gaurav Gupta, Brian G. Oliver, Kamal Dua, Md Khadem Ali, Piyush Dave
English | PDF EPUB (True) | 2023 | 276 Pages | ISBN : 9819947790 | 21.2 MB
This book discusses the role of epigenetics in pathogenesis of different pulmonary diseases, including chronic obstructive pulmonary disease, lung cancer, pulmonary tuberculosis, idiopathic pulmonary fibrosis and pulmonary infections. It also explores post-translational modifications in DNA and histones for improving the understanding of lung diseases. This book helps in understanding the epigenetic mechanisms towards the development of novel diagnostic and therapeutic approaches. Further, the book provides insight into the underlying molecular mechanisms involved in the epigenetic regulation of inflammation, which may have novel implications in designing small molecule inhibitors that target the epigenetic machinery for the effective treatment of a variety of inflammation‑related diseases. This book is a valuable resource for academics, research and industry professionals working in respiratory biology.

Free Download Epigenetics in Oncology
English | 2023 | ISBN: 303145653X | 393 Pages | PDF EPUB (True) | 30 MB
This book addresses Epigenetics in Cancer and covers the most recent advances in RNA/histone/DNA epigenetics in Oncology. RNA/histone/DNA epigenetics have been shown to play pivotal roles in cancer initiation, progression, maintenance and drug response/resistance, tumor microenvironment, cancer stem cell self-renewal, cancer metabolism, and tumor immune evasion. In particular, research in RNA cancer epigenetics has made impressive progress in the last few years.

Free Download Cancer Epigenetics
English | 2023 | ISBN: 303142364X | 730 Pages | PDF EPUB (True) | 19 MB
Epigenetic alterations are heritable changes that play a key role in human development and tissue-specific gene expression patterns. These changes can lead to alterations involved in tumor formation, imprinting, and metabolic disorders. Recent advances can help us understand the importance of epigenetic changes in both cancer development and tumor progression. In addition, epigenetic alterations may also be useful diagnostic and prognostic markers for the analysis of tumor progression.