Tag: Genetics

Free Download Russell Thompson, "ADHD: Cognitive Symptoms, Genetics and Treatment Outcomes "
English | ISBN: 1624171079 | 2013 | 138 pages | PDF | 4 MB
Attention-deficit hyperactivity disorder (ADHD) is conceptualized as a neurobehavioural condition that is characterised by developmentally inappropriate levels of inattention, impulsivity and motor over activity. It is estimated to be present in 37% of school-aged populations and can result in significant impairment in academic, social and family functioning. In this book, the authors present current research in the study of the cognitive symptoms, genetics and treatment outcomes of ADHD. Topics discussed include the disadvantages and benefits of stimulant treatment; a discussion on whether professions differ in their beliefs about the causes and treatments of ADHD; motor coordination dysfunction in ADHD; nutrition optimisation in the multi-modal treatment of ADHD; and the relation between sluggish cognitive tempo and ADHD.

Free Download Eduard Torrents, "Ribonucleotide Reductase Family: Genetics and Genomics: Genetics & Genomics"
English | ISBN: 1606924192 | 2009 | 99 pages | PDF | 6 MB
Ribonucleotide reductase (RNR), a universal enzyme present in essentially all living cells and organisms, has a central role in DNA replication and repair by catalysing production of deoxyribonucleotides from the corresponding ribonucleotides. Three major classes of RNRs are known, differing in their cofactor requirements: class I RNRs (with subclasses Ia and Ib) carry a stable tyrosyl radical and are oxygen-dependent, class II RNRs require the vitamin B12 cofactor 5′-deoxyadenosylcobalamin and are oxygen-independent, and class III RNRs carry a stable glycyl radical and are oxygen-sensitive. Despite these differences, all classes have a similar reaction mechanism and the same highly specific catalytic core structure, indicating that they evolved from a common ancestor. Biochemical studies of RNRs from selected model organisms in combination with the vast number of deduced RNR sequences from publicly available complete genomic sequences show that whereas eukaryotes and their viruses with few exceptions contain only class Ia RNRs, all three major RNR classes are found among prokaryotes and bacteriophages and quite often one organism encodes more than one class of RNR. They are compiled in an open access database, called RNRdb for Ribonucleotide Reductase database that is available athttp://rnrdb.molbio.su.se. RNRs are produced in a strictly controlled way depending upon growth phase and environmental cues. The authors describe a comprehensive summary of how the expression of RNR genes is regulated in several eubacterial organisms and in yeast. Due to RNR’s importance for the realisation of DNA replication, it has been recognised as a possible target for antiproliferative therapy. The authors present a comprehensive summary of RNR-specific inhibitors that have reached clinical trials and/or are currently used in clinical therapy.

Free Download Dhavendra Kumar, "Principles and Practice of Clinical Cardiovascular Genetics"
English | ISBN: 0195368959 | 2010 | 624 pages | PDF | 19 MB
Consisting of contributions from experts in all specialties of cardiovascular genetics and applied clinical cardiology, Principles and Practice of Clinical Cardiovascular Genetics serves as the comprehensive volume for any clinician or resident in cardiology and genetics. Each chapter provides a detailed and comprehensive account on the molecular genetics and clinical practice related to specific disorders or groups of disorders, including Marfan syndrome, thoracic and abdominal aortic aneurysms, hypertrophic, dilated and restrictive cardiomyopathies and Arrhythmogenic right ventricular cardiomyopathy, as well as many others. All sections comprehensively address cardiovasuclar genetic disorders, beginning with an introduction and including separate sections on the disease’s basic biological aspects, specific genetic mechanisms or issues, clinical aspects, genetic management (e.g., genetic diagnosis, risk assessment, genetic counseling, genetic testing), and clinical management issues. The final section exclusively addresses the management of cardiovascular genetic disorders, specifically considering stem cell therapy, genetic counseling, pharmacogenomics and the social and ethical issues surrounding disease treatment.

Free Download Zhiyuan Gong, "Fish Development and Genetics: The Zebrafish and Medaka Models "
English | ISBN: 9812388214 | 2006 | 688 pages | PDF | 34 MB
The zebrafish is the most important fish model in developmental and genetic analyses. This book contains 19 review articles covering a broad spectrum of topics, from development to genetic tools. The contents range from early development, the role of maternal factors and gastrulation, to tissue differentiation and organogenesis, such as development of the organizer, notochord, floor plate, nervous system, somites, muscle, skeleton and endoderm. The genetic tools cover morpholino knock-down, transgenics, fish cloning, transposons and genome evolution. The book also includes two chapters on genome mapping and embryonic stem cells in medaka, another important model fish. Summarizing the state-of-the-art studies of the zebrafish model and focusing on the molecular aspects of development, this book is a valuable reference for students learning the basic aspects of the zebrafish model, and for researchers seeking resources in zebrafish research.

Free Download Miroslaw Lachowicz, "FROM GENETICS TO MATHEMATICS "
English | ISBN: 9812837248 | 2009 | 244 pages | PDF | 10 MB
This volume contains pedagogical and elementary introductions to genetics for mathematicians and physicists as well as to mathematical models and techniques of population dynamics. It also offers a physicist’s perspective on modeling biological processes.Each chapter starts with an overview followed by the recent results obtained by authors. Lectures are self-contained and are devoted to various phenomena such as the evolution of the genetic code and genomes, age-structured populations, demography, sympatric speciation, the Penna model, Lotka-Volterra and other predator-prey models, evolutionary models of ecosystems, extinctions of species, and the origin and development of language. Authors analyze their models from the computational and mathematical points of view.

Free Download G. Bradley Schaefer, "Medical Genetics"
English | ISBN: 0071664386 | 2014 | 384 pages | PDF | 42 MB
A complete introductory text on how to integrate basic genetic principles into the practice of clinical medicine

Free Download Nathaniel H. Robin, "Medical Genetics: Its Application to Speech, Hearing, and Craniofacial Disorders "
English | ISBN: 1597562580 | 2008 | 182 pages | EPUB | 9 MB
Nowhere in the literature is there a book that reviews the rapidly developing field medical genetics from theories to its implications for clinical practice. Nathaniel Robin’s book fills that void. His new book covers the whole field of medical genetics from a general overview of the profession to details of effective treatment of patients with common and esoteric genetic disorders – including birth defects, hearing loss, oro-facial clefting, craiosynostosis, and much more. Crucially, as issues surrounding breakthroughs in understanding and development of new technologies in genetics have risen to the fore of the cultural consciousness, he gives coverage to the many ethical questions raised.

Free Download Philip Meneely, Rachel Dawes Hoang, Iruka N. Okeke, "Genetics: Genes, Genomes, and Evolution"
English | 2017 | pages: 775 | ISBN: 019879536X, 0198712553 | PDF | 127,3 mb
In the past, introductory biology courses based on evolution tended to give short shrift to molecular biology. Introductory molecular biology and genetics courses tended to ignore evolutionary principles altogether or included them as concluding chapters that were often skipped. Bacteria were usually treated separately from eukaryotes. Using the analysis of genomes as the organizing approach in Genetics: Genes, Genomes, and Evolution provides the opportunity to unite these topics in one narrative.

Free Download Genetics of Colorectal Cancer By John D. Potter MD, PhD, David Hunter (auth.), John D. Potter MD, PhD, Noralane M. Lindor MD (eds.)
2009 | 309 Pages | ISBN: 0387095675 | PDF | 4 MB
The last 20 years have seen a remarkable increase in knowledge of the etiology of colorectal cancer. At least three aspects are much clearer. First, known environmental agents and behaviors have been identified that increase risk (for example, diets high in meat, obesity, and smoking ) or decrease risk (for example, diets high in plant foods, aspirin, and physical activity) of colorectal cancer. Second, germline mutations in specific genes have been identified for the major inherited syndromes involving colorectal cancer (FAP, Lynch Syndrome, Juvenile Polyposis, MYH-Associated Polyposis, Li-Fraumeni Syndrome) as have variants of genes that modify the risk associated with the known environmental agents. Third, the specific tissue, cellular, and molecular disturbances that characterize the progression to different subtypes of colorectal cancer have been recently described. Genetics of Colorectal Cancer provides the most up-to-date information in each of these areas.

Free Download Superconvergence: How the Genetics, Biotech, and AI Revolutions Will Transform our Lives, Work, and World (Audiobook)
English | ASIN: B0CKNJZFP1 | 2024 | 15 hours and 44 minutes | M4B@64 kbps | 452 MB
Author: Jamie Metzl
Narrator: Jamie Metzl, James Anderson Foster
In Superconvergence, leading futurist and OneShared.World founder Jamie Metzl explores how genome sequencing, gene editing, artificial intelligence, and other technologies are not only changing our lives, but catalyzing each other in radical and accelerating ways. These technologies have the potential to improve our health, feed billions of people, supercharge our economies, and store essential information for millions of years, but can also-if we are not careful-do immeasurable harm. The challenge we face is that while the ability to engineer the world around us is advancing exponentially, our processes for understanding the scope, scale, and implications of these changes is only increasing linearly and our capacity to govern our godlike capabilities wisely is only inching forward glacially. Luckily, in Jamie Metzl we have a thinker who has followed this phenomenon for decades and who integrates science, history, politics, and international affairs to envision a future that many specialists, almost by definition, cannot see. In Superconvergence, Metzl gives us the definitive account of the technological precipice on which we stand and the map to where we go from here.