Tag: Receptors

Free Download Margaret K. Bates, "Nuclear Receptors "
English | ISBN: 1612099807 | 2011 | 185 pages | PDF | 7 MB
Nuclear receptors are involved in various aspects of intracellular signal transduction within a range of tissues and play an important role as regulators in numerous essential biological functions. In this book, the authors present topical research in the study of nuclear receptors, including glucocorticoid receptor signalling in cardiovascular disease; steroid receptor coactivators and endocrine treatment in breast cancer; the effects of nitric oxide on nuclear receptors as a tool for studying gene regulation; vitamin K as a ligand of steroid and xenobiotic receptors and androgen receptors and prostate cancer.

Free Download The Adrenergic Receptors: In the 21st Century By David B. Bylund (auth.), Dianne M. Perez (eds.)
2006 | 404 Pages | ISBN: 1588294234 | PDF | 5 MB
The adrenergic receptors control many critical functions of the heart, kidney, brain, and all organs under autonomic control. Today significant opportunities exist for molecular and genetic analysis of their function and signaling pathways. In The Adrenergic Receptors: In the 21st Century, senior scientists who have developed novel molecular approaches describe the state-of-the-art understanding of the structure and function of the adrenergic receptor subtypes, as well as the role played by these receptors in physiological and pathophysiological settings. Topics range from structure-function studies and the imaging of adrenergic receptors to the use of genetically altered mouse models and pharmacogenomics. Many of the methods described can be applied to characterize any receptor of interest. Highlights include a survey of the knockout and overexpressed mouse models, a review of the new ways that adrenergic receptors can signal, and the effects of polymorphisms on both clinical outcomes and potential gene therapy applications. Additional chapters address modern techniques for assessing adrenergic function, such as fluorescent labeling and microarrays, and offer an insightful historical survey of the extraordinary progress made in our understanding of these receptors in the twentieth century. Comprehensive and authoritative, The Adrenergic Receptors: In the 21st Century provides researchers-through its side-by-side comparison of all the adrenergic receptors (a1, a2, and b) and their subtypes-with an excellent survey of the field, including the rationale for how best to design better drugs for control of the heart, blood pressure, and related pathophysiological systems.

Free Download Wen G. Jiang, K. Matsumoto, T. Nakamura, "Growth Factors and Their Receptors in Cancer Metastasis"
English | 2001 | pages: 309 | ISBN: 0792371410, 9048157579 | PDF | 13,6 mb
about the involvement of signaling Transforming growth factor in tumor development and metastasis. plays a central role in the signaling network that controls morphogenesis, 2. THE BASICS OF growth and cell differentiation in SIGNALING multicellular organisms. The different members of this pleiotropic family of 2. 1. receptor signaling growth and differentiation factors seem to The family of growth factors regulate many processes in human disease consists of more than thirty members in and, in particular, tumor development. humans alone (15, 16). They cluster in Our understanding of how two major groups, the group composed of initiated signals are mediated has both the bone morphogenetic proteins increased dramatically in the last fifteen (BMP) and growth and differentiation years. Firstly, the prototype of factors (GDFs), and the group formed by this still constantly growing family, was the Activins, and Nodals. The two identified and cloned (1). Secondly, the groups differ in their use of receptors for family receptors were transmembrane receptors and the identified by expression cloning from subsequent activation of the mammalian tissue culture (2-7). Thirdly, transcriptional mediators (for recent genetic screens in Drosophila reviews see (13, 14, 17)).