Tag: Response

Targeting the DNA Damage Response for Cancer Therapy (Cancer Treatment and Research, 186)


Free Download Targeting the DNA Damage Response for Cancer Therapy (Cancer Treatment and Research, 186) by Timothy A. Yap, Geoffrey I. Shapiro
English | November 18, 2023 | ISBN: 3031300645 | 338 pages | MOBI | 5.67 Mb
This book discusses the latest developments in Poly (ADP-ribose) polymerase (PARP) inhibitor drug development. It focuses on the translational and clinical development of the latest drugs, as well as the evidence for regulatory approval of PARP inhibitors in multiple different molecular subtypes and tumor indications. The most-up-to-date information on basic scientific research on DNA repair pathways and the DNA Damage Response (DDR) is also covered. Every chapter contains insight into the preclinical, translational along with clinical aspects of a specific DDR inhibitor with key and expert opinion points reinforcing the most important concepts detailed to enable the reader to develop a deep understanding of the topic.

(more…)

Endpoint Detection and Response Essentials Explore the landscape of hacking, defense, and deployment in EDR


Free Download Endpoint Detection and Response Essentials: Explore the landscape of hacking, defense, and deployment in EDR by Guven Boyraz
English | May 24, 2024 | ISBN: 1835463266 | 170 pages | PDF | 9.82 Mb
Elevate your expertise in endpoint detection and response by mastering advanced EDR/XDR concepts through real-life examples and fortify your organization’s cyber defense strategyKey FeaturesLearn how to tackle endpoint security problems in your organizationApply practical guidance and real-world examples to harden endpoint securityImplement EDR/XDR tools for optimal protection of digital assetsPurchase of the print or Kindle book includes a free PDF eBookBook Description

(more…)

IT Security Champion Incident Response


Free Download IT Security Champion Incident Response
Published 9/2024
MP4 | Video: h264, 1920×1080 | Audio: AAC, 48 KHz
Language: English | Size: 27.96 MB | Duration: 13m 35s
Incident response plans are critical to successfully responding to cyber security attacks. This course will teach you about the role of IT in incident response.

(more…)

Public Response to Alerts and Warnings on Mobile Devices Summary of a Workshop on Current Knowledge and Research Gaps


Free Download Public Response to Alerts and Warnings on Mobile Devices: Summary of a Workshop on Current Knowledge and Research Gaps By Committee on Public Response to Alerts and Warnings on Mobile Devices: Current Knowledge and Research Gaps, Computer Science and Telecommunications Board, Division on Engineering and Physical Sciences, National Research Council
2011 | 102 Pages | ISBN: 0309185130 | PDF | 6 MB
This book presents a summary of the Workshop on Public Response to Alerts and Warnings on Mobile Devices: Current Knowledge and Research Gaps, held April 13 and 14, 2010, in Washington, D.C., under the auspices of the National Research Council’s Committee on Public Response to Alerts and Warnings on Mobile Devices: Current Knowledge and Research Needs. The workshop was structured to gather inputs and insights from social science researchers, technologists, emergency management professionals, and other experts knowledgeable about how the public responds to alerts and warnings, focusing specifically on how the public responds to mobile alerting.

(more…)

Human Response to Vibration


Free Download Human Response to Vibration By Neil J. Mansfield
2004 | 248 Pages | ISBN: 041528239X | PDF | 4 MB
Through continued collaboration and the sharing of ideas, data, and results, the international community of researchers and practitioners has developed an understanding of many facets of the human response to vibration. At a time when the EU is preparing to adopt a directive on health risks arising from occupational exposure to vibration, Human Response to Vibration offers authoritative guidance on this complex subject. Individual chapters in the book examine issues relating to whole-body vibration, hand-arm vibration, and motion sickness. Vibration measurements and standards are also addressed. This book meets the needs of those requiring knowledge of human response to vibration in order to make practical improvements to the physical working environment. Written with the consultant, practitioner, researcher, and student in mind, the text is designed to be an educational tool, a reference, and a stimulus for new ideas for the next generation of specialists.

(more…)

System Dynamics Modeling, Simulation, and Response


Free Download System Dynamics: Modeling, Simulation, and Response
English | 2025 | ISBN: 1032685638 | 550 Pages | PDF (True) | 13 MB
Presenting transient response analyses of first- and second-order systems subjected to various inputs, the book provides a thorough discussion of computational analyses of transient responses using MATLAB®/Simulink and 20-sim software. It introduces the Lagrangian method and its application in handling mechanical and electrical systems. The book reviews the classical method for solving differential equations and includes Laplace transforms.

(more…)

Principles and Practice of Emergency Research Response


Free Download Principles and Practice of Emergency Research Response
English | 2024 | ISBN: 303148407X | 1122 Pages | PDF (True) | 102 MB
Unlocking the Future of Infectious Disease Research ResponseIn a world where emerging infectious diseases constantly threaten humanity, advances in science and technology promise defense against future pathogens before they cause pandemics. The field of emergency research response and preparedness remains in its infancy, however. Not until the 2014 West African Ebola outbreak was accelerated research broadly recognized as a crucial component of emergency response. Many outbreaks and one global pandemic later, it is clear the world must be prepared to launch accelerated research responses to prevent or mitigate infectious disease outbreaks, epidemics, and pandemics. Yet this nascent field is rife with critical scientific, ethical, and policy questions. How can local, national, and global systems collaborate across disciplines and political boundaries to protect health security? How can we conduct rigorous research in fragile or failed nation-states? What is needed for equitable distribution of vaccines and therapeutic medicines in short supply? How can we accelerate trials of vaccines and therapeutics during an emergency without compromising scientific rigor or ethical standards? How do we integrate communities and stakeholders into research preparedness and response? The editors bring decades of experience to their collaboration with renowned research scientists and health policy experts. Together they have crafted a compendium that proposes normative standards and offers practical guidance for preparedness and rapid research response. This pioneering, open access textbook presents principles and practices forged from experience in health emergencies – insights that illuminate a path forward for research response and preparedness.

(more…)

Milankovitch and Climate Understanding the Response to Astronomical Forcing


Free Download Milankovitch and Climate: Understanding the Response to Astronomical Forcing by A. Berger, J. Imbrie, J. Hays, G. Kukla, B. Saltzman
English | PDF | 1984 | 377 Pages | ISBN : 9027717788 | 28.7 MB
In recent years there have been many attempts to use simple energy balance models to simulate the climatic changes that occurred during the Pleistocene by altering the earth’s energy budget through sma 11 orb ita 1 element changes. Attempts with mean annual models which resolved latitudinal variation in tem- perature failed to produce large ice sheets when the obliquity was changed a few degrees (1,2) although these early models were generally more sensitive than today’s parameterizations would suggest. Attention then turned to seasona 1 energy balance models, since the primary insolation anomaly is seasonal. Sel- lers (3), Thompson and Schneider (4) and North and Coakley (5) developed simple models which were either effectively zonally averaged or included a separate land and ocean surface tempera- ture at each latitude. Suarez and Held (6) added some vertical resolution in their model. All included the ice-albedo feedback mechanism and horizontal transport which was essentially diffu- sive. The models shared one interesting property : they remai- ned rather insensitive to the sizes of orbital changes which were thought to have occurred in the Pleistocene. There were minor differences in the results and some pointed toward possi- ble ways out of the puzzle but curiously the mechanisms of ice- -albedo feedback in the insolation and water vapor feedback in the infrared terms ·seemed too weak to account for the ice ages (for a review of these models see (7) and more recently (8)).

(more…)

Milankovitch and Climate Understanding the Response to Astronomical Forcing


Free Download Milankovitch and Climate: Understanding the Response to Astronomical Forcing by A. Berger, J. Imbrie, J. Hays, G. Kukla, B. Saltzman
English | PDF | 1984 | 377 Pages | ISBN : 9027717788 | 28.7 MB
In recent years there have been many attempts to use simple energy balance models to simulate the climatic changes that occurred during the Pleistocene by altering the earth’s energy budget through sma 11 orb ita 1 element changes. Attempts with mean annual models which resolved latitudinal variation in tem- perature failed to produce large ice sheets when the obliquity was changed a few degrees (1,2) although these early models were generally more sensitive than today’s parameterizations would suggest. Attention then turned to seasona 1 energy balance models, since the primary insolation anomaly is seasonal. Sel- lers (3), Thompson and Schneider (4) and North and Coakley (5) developed simple models which were either effectively zonally averaged or included a separate land and ocean surface tempera- ture at each latitude. Suarez and Held (6) added some vertical resolution in their model. All included the ice-albedo feedback mechanism and horizontal transport which was essentially diffu- sive. The models shared one interesting property : they remai- ned rather insensitive to the sizes of orbital changes which were thought to have occurred in the Pleistocene. There were minor differences in the results and some pointed toward possi- ble ways out of the puzzle but curiously the mechanisms of ice- -albedo feedback in the insolation and water vapor feedback in the infrared terms ·seemed too weak to account for the ice ages (for a review of these models see (7) and more recently (8)).

(more…)