Tag: RNA

The Catalyst RNA and the Quest to Unlock Life’s Deepest Secrets [Audiobook]


Free Download Thomas R. Cech, Joshua Saxon (Narrator), "The Catalyst: RNA and the Quest to Unlock Life’s Deepest Secrets"
English | ASIN: B0D9HS6B3M | 2024 | MP3@64 kbps | ~06:54:00 | 190 MB
For over half a century, DNA has dominated science and the popular imagination as the "secret of life." But over the last several decades, a quiet revolution has taken place. In a series of breathtaking discoveries, the biochemist Thomas R. Cech and a diverse cast of brilliant scientists have revealed that RNA-long overlooked as the passive servant of DNA-sits at the center of biology’s greatest mysteries: How did life begin? What makes us human? Why do we get sick and grow old? In The Catalyst, Cech finally brings together years of research to demonstrate that RNA is the true key to understanding life on Earth, from its very origins to our future in the twenty-first century.
A gripping journey of discovery, The Catalyst moves from the early experiments that first hinted at RNA’s spectacular powers, to Cech’s own paradigm-shifting finding that it can catalyze cellular reactions, to the cutting-edge biotechnologies poised to reshape our health. We learn how RNA may have jump-started life itself, and how, at the same time, it can cut our individual lives short through viral diseases and cancer. We see how RNA is implicated in the aging process and explore the darker depths of the supposed fountain of youth, telomerase. And we catch a thrilling glimpse into how RNA-powered therapies may enable us to improve and even extend life beyond nature’s current limits.
(more…)

RNA Folding Methods and Protocols


Free Download RNA Folding: Methods and Protocols By Ivo L. Hofacker, Ronny Lorenz (auth.), Christina Waldsich (eds.)
2014 | 340 Pages | ISBN: 1627036660 | PDF | 8 MB
Focusing on in vitro and intracellular RNA structure formation, RNA Folding: Methods and Protocols provides a comprehensive collection of experimental protocols which are suitable to dissect RNA folding pathways and to characterize the structure of RNA folding intermediates at nucleotide or even atomic resolution. The presented techniques include powerful tools with a long tradition in RNA research as well as more advanced, novel methods, thus the methods span multiple disciplines, including molecular biology, biochemistry, biophysics, and computational biology. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Practical and authoritative, RNA Folding: Methods and Protocols serves as a vital reference for researchers attempting to gain insights into the secrets of this astounding macromolecule.

(more…)

Machine Learning in Single-Cell RNA-seq Data Analysis


Free Download Machine Learning in Single-Cell RNA-seq Data Analysis
English | 2024 | ISBN: 9819767024 | 106 Pages | PDF EPUB (True) | 14 MB
This book provides a concise guide tailored for researchers, bioinformaticians, and enthusiasts eager to unravel the mysteries hidden within single-cell RNA sequencing (scRNA-seq) data using cutting-edge machine learning techniques. The advent of scRNA-seq technology has revolutionized our understanding of cellular diversity and function, offering unprecedented insights into the intricate tapestry of gene expression at the single-cell level. However, the deluge of data generated by these experiments presents a formidable challenge, demanding advanced analytical tools, methodologies, and skills for meaningful interpretation. This book bridges the gap between traditional bioinformatics and the evolving landscape of machine learning. Authored by seasoned experts at the intersection of genomics and artificial intelligence, this book serves as a roadmap for leveraging machine learning algorithms to extract meaningful patterns and uncover hidden biological insights within scRNA-seq datasets.

(more…)

Charting a Future for Sequencing RNA and Its Modifications A New Era for Biology and Medicine


Free Download Charting a Future for Sequencing RNA and Its Modifications
by National Academies of Sciences, Engineering, and Medicine;Health and Medicine Division;Division on Earth and Life Studies;Board on Health Sciences Policy;Board on Life Sciences;Toward Sequencing and Mapping of RNA Modifications Committee;

English | 2024 | ISBN: 0309706955 | 274 pages | True PDF EPUB | 20.56 MB

(more…)

RNA Structure and Function (RNA Technologies, 14)


Free Download RNA Structure and Function (RNA Technologies, 14) by Jan Barciszewski
English | November 4, 2023 | ISBN: 3031363892 | 677 pages | MOBI | 31 Mb
This book focuses on the current status of our understanding of RNA, a key biological molecule. The various RNAs covered are messenger RNA, ribosomal RNA, transfer RNA, noncoding RNAs, modified nucleosides, and RNA enzymes. The different chapters detail methods to investigate RNA structure and function, the chemistry of modified RNAs, and the latest advances in our understanding of the vast array of biological processes in which RNA is involved.RNA, in one form or another, touches almost everything in a cell. RNA has both structural and catalytic properties. RNA fulfills a broad range of functions. These molecules are no longer seen as passive elements transferring the genetic information from DNA into proteins but regulate the activity of genes during development, cellular differentiation, and changing environments. RNAs are involved in various aspects of cell physiology and disease development. Discoveries of RNA with unexpected diverse functions in healthy and diseased cells,such as the role of RNA as both the source and countermeasure to cancer or severe viral infection, stimulate new trends, passion, and solutions for molecular medicine.

(more…)

Looking at Ribozymes Biology of Catalytic RNA


Free Download Looking at Ribozymes: Biology of Catalytic RNA
English | 2024 | ISBN: 1786309777 | 176 Pages | PDF | 29 MB
Behind the neologism "ribozymes" lies a family of fascinating molecules, ribo-enzymes, which have been relatively little studied. These catalytically active RNAs are found in all strata of life, from viruses to the human genome.

(more…)

Looking at Ribozymes Biology of Catalytic RNA


Free Download Looking at Ribozymes: Biology of Catalytic RNA
English | 2024 | ISBN: 1786309777 | 176 Pages | PDF | 29 MB
Behind the neologism "ribozymes" lies a family of fascinating molecules, ribo-enzymes, which have been relatively little studied. These catalytically active RNAs are found in all strata of life, from viruses to the human genome.

(more…)

Double-Stranded RNA


Free Download Double-Stranded RNA
English | 2024 | ISBN: 1071637010 | 271 Pages | PDF EPUB (True) | 11 MB
This detailed volume examines classical and cutting-edge methods involving double-stranded RNA (dsRNA), specifically regarding isolation, visualization, characterization, production, and application. Many protocols, such as co-immunoprecipitation-based isolation of double-stranded RNA-associated protein complexes, identification of mycoviruses by dsRNA extraction, application of dsRNA for fungi disease management (Sclerotinia sclerotiorum and Botrytis cin), and production of double-stranded RNA in plants by plant viral vectors for gene silencing, can also be easily adapted for identification of viruses from other organisms, control of other pathogens, and fundamental research. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips for troubleshooting and avoiding known pitfalls.

(more…)

Bacterial Regulatory RNA (2nd Edition)


Free Download Bacterial Regulatory RNA (2nd Edition)
English | 2024 | ISBN: 1071635646 | 746 Pages | PDF EPUB (True) | 46 MB
This second edition details new and updated methods used for studying prokaryotic non-coding RNAs and their protein accomplices. Chapters detail discovery of ncRNAs, characterization of their structure, functions, and their interactomes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

(more…)