Tag: Signalling

Free Download GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity By Christian Nanoff, Michael Freissmuth (auth.), Denis J. Dupré, Terence E. Hébert, Ralf Jockers (eds.)
2012 | 300 Pages | ISBN: 9400747640 | PDF | 8 MB
Main Question: G protein coupled receptors are involved in highly efficient and specific activation of signalling pathways. How do GPCR signalling complexes get assembled to generate such specificity? In order to answer this question, we need to understand how receptors and their signalling partners are synthesized, folded and quality-controlled in order to generate functional proteins. Then, we need to understand how each partner of the signalling complex is selected to join a complex, and what makes this assembly possible. GPCRs are known to be able to function as oligomers, what drives the assembly into oligomers and what will be the effects of such organization on specificity and efficacy of signal transduction. Once the receptor complexes are assembled, they need to reach different locations in the cell; what drives and controls the trafficking of GPCR signalling complexes. Finally, defects in synthesis, maturation or trafficking can alter functionality of GPCRs signalling complexes; how can we manipulate the system to make it function normally again? Pharmacological chaperones may just be part of the answer to this question.

Free Download Tariq Aftab, "Plant Growth Regulators: Signalling under Stress Conditions"
English | ISBN: 3030611523 | 2021 | 518 pages | PDF | 10 MB
Agriculture faces many challenges to fulfil the growing demand for sustainable food production and ensure high-quality nutrition for a rapidly growing population. To guarantee adequate food production, it is necessary to increase the yield per area of arable land. A method for achieving this goal has been the application of growth regulators to modulate plant growth. Plant growth regulators (PGRs) are substances in specific formulations which, when applied to plants or seeds, have the capacity to promote, inhibit, or modify physiological traits, development and/or stress responses. They maintain proper balance between source and sink for enhancing crop yield. PGRs are used to maximize productivity and quality, improve consistency in production, and overcome genetic and abiotic limitations to plant productivity. Suitable PGRs include hormones such as cytokinins and auxins, and hormone-like compounds such as mepiquat chloride and paclobutrazol. The use of PGRs in mainstream agriculture has steadily increased within the last 20 years as their benefits have become better understood by growers. Unfortunately, the growth of the PGR market may be constrained by a lack of innovation at a time when an increase in demand for new products will require steady innovation and discovery of novel, cost-competitive, specific, and effective PGRs.