Tag: Solubility

Free Download Christoph Saal, "Solubility in Pharmaceutical Chemistry"
English | ISBN: 3110545136 | 2020 | 370 pages | EPUB, PDF | 7 MB + 3 MB
This book describes the physicochemical fundamentals and biomedical principles of drug solubility. Methods to study and predict solubility in silico and in vitro are described and the role of solubility in a medicinal chemistry and pharmaceutical industry context are discussed. Approaches to modify and control solubility of a drug during the manufacturing process and of the pharmaceutical product are essential practical aspects of this book.

Free Download Predicting Solubility of New Drugs: Handbook of Critically Curated Data for Pharmaceutical Research
English | 2024 | ISBN: 1032617675 | 1730 Pages | PDF (True) | 459 MB
In pharmaceutical research, solubility plays a key part in the assessment of pharmacokinetic risks. Poor drug absorption, reduced efficacy, excessive metabolism, and adverse reactions are frequently related to issues of drug solubility. During early discovery research at pharmaceutical companies, many thousands of molecules are considered. Most are rejected due to perceived unfavorable properties. Here the author uses the Wiki-pS0TM database, which forms the backbone of this unique handbook. Also discussed is the emerging class of therapeutically promising research molecules called PROTACs (proteolysis-targeting chimeras), showing a propensity for ‘undruggable’ targets.